Paper Title
Bioactive Compounds A Novel Approach in Prostate Cancer Management: A Review from Molecular Mechanisms to Clinical Applications

Abstract
Prostate cancer (PCa) still remains a major global health issue, with increasing cases and constant therapeutic issues that includes treatment resistance and toxicity. This review tries to dive into the world of phytochemicals and examines the potential of phytochemicals as a novel approach for PCa management. We investigate and analyse the molecular mechanisms and present clinical evidence for major compounds including lycopene, sulforaphane, curcumin, resveratrol, and quercetin. These bioactive compounds show polygenic anticancer effects by targeting multi-faceted markers of cancer – causing apoptosis, regulating androgen receptor signaling, restricting angiogenesis, and reversing epigenetic dysregulation. Analyses of preclinical evidence show promising results, while clinical translation still faces many challenges such as low bioavailability. We have identified many innovative strategies to overcome these limitations and boost the research process for making it adoptable in future, including nanotechnology-driven delivery systems, and AI-guided discovery of new phytochemicals. Coming out strategies like exosomal delivery, biomimetic nanocarriers, and generative AI models for molecule design show significant commitments. By combining phytochemicals with traditional therapies and utilizing latest developed technologies, there is major potential of developing more efficient and much less toxic treatment strategies for PCa. Although, more research is needed to enhance the formulations, point out accurate mechanisms, and confirm clinical efficiency through accurate trials.