Paper Title
COMPARATIVE EFFECT OF ANTIHYPERTENSIVE DRUGS (LISINOPRIL AND AMLODIPINE) WITH MORINGA OLEIFERA LEAF EXTRACT ON SOME LIVER ENZYMES

Abstract
Abstract - Drug related liver disorders have been the most important form of liver disease in the last decade. This is due to the negligence and alarming increase in drug abuse and also due to the toxic effects of inadequate therapies employed in the treatment of various diseases. With regards to this, this research aimed at using Moringa oleifera leaf extract to achieve hepatoprotective activity in Dexamethasone-salt induced hypertension in albino wister rats using liver enzymes as biomarkers; and to compare the effect with the conventional drugs (Lisinopril and Amlodipine). A total of 30 albino wister rats were divided into six groups with 5 animals in each group. Group 1 served as the negative control (Un-induced), Group 2 served as the positive control (Induced but not treated) while Groups 3, 4, 5 and 6 were the test groups (Induced and treated with conventional drugs and graded concentrations of Moringa oleifera (leaf extract). All the groups were fed ad libitum with standard diet and water throughout the three weeks experimental period. Blood samples were collected and the serum was used to measure the levels of liver enzymes (ALP, ALT and AST) using COBAS C311 auto analyzer. Data obtained were analyzed using the statistical package for social sciences (SPSS) version 27.0. There was nostatisticalsignificant difference (P>0.05) in the levels of serum ALP, ALT and AST between albino wister rats exposed to the conventional drugs. There was also no statistical difference in the levels of serum ALP, ALT and AST between albino wister rats exposed to the low and high dose of the extract. There was also no statisticalsignificant difference in the levels of serum ALP, ALT and AST between albino wister rats exposed to a combination of the conventional drugs and the low dose of the extract. Based on these results, it can be concluded that Moringa oleifera leaf extract could be used in combination with conventional drugs for the treatment and management of liver diseases and hypertension. Keywords - Comparative, Lisinopril, Amplodipine, Moringa Leaf Extract, and Liver Enzymes.