Paper Title
Effectiveness Of Prone Position In Acute Respiratory Distress Syndrome For Covid-19 Patients: A Meta-Analysis

Abstract
Objectives: To examine the effectiveness of prone positioning on COVID-19 patients with acute respiratory distress syndrome in patient’s non-invasive ventilation. Research methodology: A comprehensive search was conducted in Cochrane Library, Embase, COVID-19 database, CINAHL, Scopus, MEDLINE, and Web of Science without language restrictions. All studies with prospective and experimental designs evaluating the effect of prone position with patients COVID-19 related to acute respiratory distress syndrome were included. R software 4.0.2assessed the effectiveness of respiratory rehabilitation adopting the random-effects model and presenting standardized mean differences (SMDs). Heterogeneity was determined by Cochran’s Q and I2. Results: Of 142 results, 5 articles were eligible and included in the final analysis. Prone position had a statistically significant effect in improving SpO2 (p=0.001), with a relatively large effect size of standardized mean difference 3.39 (95% CI from 1.30 to 5.48) with I297.2% and Q-value at 142.99 (p <0.0001). Conclusions: Our findings demonstrate that prone position significantly improved oxygen saturation in COVID-19 patients with acute respiratory distress syndrome. Prone positioning should be implemented as an early management strategy to improve the outcomes of patients. Keywords - COVID-19, Acute Respiratory Distress Syndrome, Prone Position, Corona virus 2, Respiratory Fail