Paper Title
Cinnamaldehyde Modulates Biochemical Alterations in Female Wistar Albino Rats Induced with Ovarian Cancer

Abstract
Ovarian cancer is still the deadliest of all gynecologic malignancies in women worldwideand often present at an advanced stage with poor prognosis. The currently available anticancer drugs that are used for treatment of ovarian cancer have serious side effects limiting their chronic use. Therefore, novel targets for an early diagnosis and better treatment options for these tumors are urgently needed. Several epidemiological evidences strongly suggest that steroid hormones, primarily estrogens and progesterone, are implicated in ovarian carcinogenesis. The role of reproductive hormones in ovarian carcinogenesis remains a key topic of research. Therefore, the current study was designed to investigate the effect of cinnamaldehyde on reproductive hormones in experimentally induced ovarian cancerrats using 7,12-dimethylbenz(a)anthracene (DMBA).Cinnamaldehyde is an active compound isolated from the stem bark of Cinnamomum, a traditional oriental medicinal herb and has been widely used in Asia for more than 4000 years. Cinnamaldehyde has different biological activities including antimicrobial, anti-inflammatory, antiviral, antioxidant, antitumor were reported by many investigators.Animals were randomly allocated into VI groups: Group -I served as a control with normal water and group-II was vehicle control (sesame oil which was used as dissolution medium for cinnamaldehyde). The rats in group III-VI were given with single dose of 7,12 Dimethyl benzanthracene (100 µg) dissolved in 10 µL of sesame oil to surgically exposed left ovary andmaintained up to 180 days for initiate ovarian carcinogenesis. Over the next 180 days, group-III rats considered to be DMBA control and rats in group IV and V were administrated with cinnamaldehyde (25mg/k.gb.w& 50mg/k.gb.w) along with DMBA for 90 days. Rats in group VI were given withCarboplatin as standarddrug (165mg/k.gb.w). Serum levels of Estrogen, progesterone, LH, FSH were estimated using ELISA. The results showed that significant increase in serum level of LH, FSH and decreased Estrogen, progesterone in only DMBA treated group when compared with control groups. Also, there was a significant decrease in serum level of LH, FSH and increased Estrogen,progesterone in cinnamaldehyde treated groups (dose dependent)and carboplatin treated group when compared to only DMBA treated group. The results of the present study suggested that cinnamaldehyde have anticancer activity and further investigationsare needed for evaluating the anticancer potential and mechanism of its action. Keywords - Cinnamaldehyde, DMBA, Ovarian cancer, Reproductive hormones