Paper Title
Study on Interaction Analyses for Cytotoxicity of Natural Products by Using Experimental Design

Abstract
Most existing approaches for cytotoxicity analysis of multi-components natural products may often not consider interactions among a number of components in a natural product without using a designed experiment. This analysis problems include a number of difficulties associated with a dimensionality, such as simultaneous consideration of many ingredients, a huge number of experimental runs, statistical errors related to high dimensions, etc. To this end, this study is to perform systematic statistical designed experimental methods (i.e., mixture experimental design). In order to consider both a number of runs and their associated statistical efficiencies, a simplex lattice design was utilized in this study. In addition, this research also investigates a tradeoff between hepatotoxicity and synergy effects based on a cell viability. The primary goal of this research is to obtain an optimal combination of multi-components by maximizing the cell viability with low cytotoxicitand high synergy effects. To verification purposes, this paper demonstrates an experimental design, its associated statistical analysis results, and an optimization approach and its related results. Keywords: Design of experiment, Mixture design, Multi-components, Natural product, Cytotoxicity