Paper Title
Sargassumpolycystumextract Attenuates Dyslipidemia In Streptozotocin-Induced Diabetic Rats

Abstract
Sargassumpolycystum contain phlorotannin, a natural compound that classified in polyphenol. Polyphenol have been known able to decrease blood glucose level on diabetics. High glucose level can induce dyslipidemia on diabetes. The objective of this study was to evaluate S. polycystum extract on decreasing of the dyslipidemia in diabetic rats. S. polycystum was obtained from the Talango coastline, Sumenep District, East Java, Indonesia. S. polycystumwas macerated by methanol (1:3 ; b/v), concentrated, flushed by nitrogen and freeze dried, respectively, to acquire the extract. Rattusnorvegicus was induced to diabetes animal model by the injection of streptozotocin in intraperitoneal part of rats. The rats were collected to six groups, i.e.: normal, diabetic, diabetic treated by glyclazide, diabetic treated by 200; 400 and 600 mg/kg body weight of S. polycystum extract, respectively. Blood glucose level of rats were observed each nine days for 45 days. The end of experiment, rats were sacrificed and the blood obtained from aorta. The cholesterol, HDL, LDL and Triglyceride levels of animalwere analyzed by commercial kits. The result showed that the diabetic groups suffer hyperglycemia and dyslipidemia. The diabetic rats treated by 600 mg/kg body weight of S. polycystum extract showed the highest of reducing of blood glucose, cholesterol, LDL and triglyceride levels, respectively, and increasing of HDL level. In conclusion the 600 mg/kg body weight of S. polycystumextract reduces the dyslipidemia of diabetic and it is potential as anti-hypercholesterolemic agent on diabetes. Keywords - Cholesterol, Diabetes mellitus, High Dense Lipoprotein, Low Dense Lipoprotein, Sargassumpolycystum, Triglyceri