Paper Title
Effect of Short and Long Term Foot Shock Stress on Histology of Liver, Spleen and Kidney in Old Age Albino Mice

Abstract
During Induction ofstress hormone epinephrineconcentration increases many times in the body. In the present study short term (5 days) and long term (21 days) foot shock stress was given to Albino mice of old ageof BALB C strain (481 days old) to see any the histological changes inliver, spleen and kidney.Mice subjected to longterm stressshowedin liver vacuolization, elongation of nucleus of hepatic cells and infiltration. While in kidney dilated Bowman�s capsule,frequent vacuolization in renal cortex,degeneration of cells of proximal convoluted tubule, whereas in spleen there was increase in the size of the follicles and red pulpmorphology of the parenchyma (increase in red pulp).Thus it is concluded from the entire study thatlong term stress causes degeneration in hepatic cells, infiltration in liver,degeneration of glomerulus, bowman�s capsule, convoluted tubulesin kidney which finally leading to both hepato-toxicity and nephro-toxicity.In spleen longterm stress alters the immuneresponsein Old age Albino Mice by inducing morphology changes, explaining in part the indicating impaired immunity that develops in organisms that are exposed to chronic stress. Keywords: Foot shock stress, liver, spleen, kidney, old age.