Hepatocurative Effects of Petroleum Spirit Root Extract of Sodom Apple (C. Procera) on CCL4 Induced Hepatotoxicity Rats
The effects of petroleum spirit root extracts of C. procera and livolin on liver function indices of CCl4 induced hepatotoxicity rats was evaluated on forty (40) albino rats which were grouped into four (I, II, III and IV) of 10 rats each, 120mg/kg CCl4 was administered to rats in group II, III, and IV intramuscularly followed by oral administration of 10mg/kg livolin and petroleum spirit root extract of C. procera to group III and IV respectively. Analysis of variance (ANOVA) for multiple comparisms test were used to compare the result of the liver and kidney biochemical parameters from the test and control and control group at 10 days interval for 20 days. The hepatic biochemical markers alanine aminotransferase (ALT), Aspartate amino transferase (AST), alkaline phosphatase (ALP) of the toxicant group (Gp II) were significantly higher (P<0.001), while group III (treated with livolin) statistically decreased (P<0.05) when compared with control (Gp I), this confirms the toxicity and treatment with livolin respectively. Oral administrations of the extracts lower all the liver function markers and increase the concentration of urea and albumin. This show the hepatocurative effect of the extract against CCl4 induced rats. These effects may be due to the active components present in the root similar to those found in livolin.
Keywordsó Calotropis Procera, Hepatotoxicity, Livolin, Carbon Tetrachloride.