Development Of Ph Sensitive Magnetic Nanocomposites For Targeted Drug Delivery In Cancer Therapy
In the field of medicine magnetic nanocomposite materials are gaining interest due to their excellent magnetic properties, stability, and good biocompatibility. In this study we have developed simple, less expensive, less time consuming method for the preparation of magnetic starch – iron oxide nanocomposite (abbreviated as SION) by using supercritical CO2. The magnetic SION were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). An anti tumor drug doxorubicin, was inserted in the composite through incubation mixing method. In addition, the drug release profile was studied at different pH, to determine the influence of the pH on release of the drug. The drug release was monitored and quantified using the ultraviolet-visible spectrophotometer (UV-Vis), for doxorubicin. Results demonstrated that SION presented a good magnetic property, which enable the magnetic composite to target a specific place or tissue under the influence of external magnetic field. Furthermore, in the presence of acidic medium the release is comparably faster than in neutral pH which almost ceased at basic pH. At different pH the magnetic SION were able to perform a controlled pH stimulus release of drug. This phenomenon may be useful to perform a fine tuning of the system, allowing the easier adjust of the speed, site and amount of released drug, useful to improve medical treatments and even the welfare of the patients.
Keywords— Drug Delivery, Magnetic Nanocomposites, X-ray Differection, pH Stimulus, Starch-Iron Oxide Nanocomposite.