Paper Title
Dynamic Mechanical Analysis of Polyvinyl Alcohol-Graft-Lactic Acid Hydrogel: In Pure Form and Propranolol HCl Loaded Form

Abstract
This work aims to study the transition temperatures behavior of the adhesive hydrogel films by dynamic mechanical analysis (DMA). The adhesive hydrogel film made from polyvinyl alcohol – graft – lactic acid (PVA-g-LA) that is synthesized by eco-friendly synthesis method, and incorporated the propranolol HCl as a model drug. The compositions between of PVA and LA are prepared. The PVA pellets are dissolved in ultrapure water by heating it on a water bath at 70±2ºC and being continuously cooled down to room temperature, then the LA solution and propranolol HCl powder are slowly added into clearly PVA solution with the help of a mechanical stirrer for 60 min to form a homogeneously gel-like mixture solution. The gel-like mixture solution is cured at high temperature in an oven to produce the adhesive hydrogel film. The pure form and PPH loaded PVA-g-LA adhesive hydrogel film samples were scan at different frequency in ranged of 5 – 40 Hz. The result shown that the transition temperatures in range of 200-230C depends on the ratios of PVA and LA and propranolol HCl. Therefore, the results demonstrate that the prepared adhesive hydrogel films allow the use of conventional DMA instruments for the analysis of pharmaceutical product, however the technique requires more development to further reduce its theoretical limit of detection. Keywords - Dynamic Mechanical, Polyvinyl Alcohol-graft-Lactic Acid, Hydrogel, Propranolol HCl